Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) is a protein that in humans is encoded by the PPARGC1A gene.[4] PPARGC1A is also known as human accelerated region 20 (HAR20). It may, therefore, have played a key role in differentiating humans from apes.[5] PGC-1α is the master regulator of mitochondrial

Aliases: PPARGC1A, LEM6, PGC-1(alpha), PGC

PGC-1α和能量代谢的关系_临床医学_医药卫生_专业资料。过氧化物酶体增殖物激活受体γ辅激活因子1α(peroxlsome proliferator—activated receptor-γ coactlvator—1α,PGC—1α),是近几年来发现的一种核转

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PGC-1 小川 渉 (神戸大学大学院 医学系研究科) PGC-1 は転写因子PPAR に結合する転写コアクチベーターとして同定された分子であり、エ ネルギー産生や熱消費に関わる多くの遺伝子発現を制御する。白色脂肪細胞にPGC-1αを導入

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过氧化物酶体增殖物激活受体-γ共激活因子-1α(PGC-1α)在控制能量稳态中用作诱导型共调节剂。 PGC-1α是GLUT4和线粒体基因的强大转录共调节因子,包括电子传递系统的组分。 PGC-1α在具有高能量需求的组织中大量表达,包括棕色脂肪组织,心脏,骨骼肌

PGC-1α 在骨骼肌内大量表达,特别是在慢肌纤 维中. PGC-1α 在 肌 酸 激 酶 ( muscle creatine kinase, MCK) 作用下从白色糖酵解型的快肌纤维变成红色 氧 化 型 的 慢 肌 纤 维,且 能 提 高 收 缩 类 蛋 白 的 表 第 11 期 李 博等: PGC-1α 的功能与代谢病

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概要: PGC-1α とは

2/1/2017 · PGC-1α promotes ATP production and energy homeostasis during bioenergetic crises, which renders cells resistant to necrosis and apoptosis(). While PGC-1α has been implicated in tumorigenesis(13, 14), its function in metastasis remains unknown.

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1/10/2004 · PGC-1α plays essential and diverse functions in the control of metabolism ranging from mitochondrial biogenesis and respiration to hepatic gluconeogenesis and muscle fiber-type switching. In a paper by Lin et al. (2004)(this issue of Cell), the characterization of PGC

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PGC-1α对线粒体生物合成功能的调控.pdf 4 页 本文档一共被下载: 次 ,您可全文免费在线阅读后下载本文档。 下载提示 1.本站不保证该用户上传的文档完整性,不预览、不比对内容而直接下载产生的反悔问题本

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運動による糖代謝促進へのPGC-1αの関与 生活習慣病研究部 三浦 進司 GLUT4プールの増加 GLUT4 血糖 運動 血液 骨格筋細胞 糖の代謝 脂肪の燃焼 ミトコンドリアの増加 他の因子? PGC-1α 運動によるGLUT4増加には、PGC-1α以外の因子が関与している?

PGC-1α(PPARγ coactivator 1α) PPARγに結合するコアクチベーターとして同定された転写制御因子。白色脂肪細胞においてはミトコンドリア生合成の増強やUCP1の発現増加などによる褐色脂肪細胞様変化を生じさせる。運動によって増加するとされ、骨格

1/12/2006 · Peroxisome proliferator-activated receptor-γ coactivator (PGC)-1α is a member of a family of transcription coactivators that plays a central role in the regulation of cellular energy metabolism. It is strongly induced by cold exposure, linking this environmental stimulus

Puigserver P,Spiegelman BM.Peroxisome proliferatoractivated receptorγ coactivator 1α(PGC1α):transcriptional coactivator and metabolic regulator\[J\].Endocr Rev,2003,24(1):78-90. [22] Lin JD,Handschin C,Spiegelman BM.Metabolic control through the PGC

使用 PGC-1α (3G6) Rabbit mAb 对转染空载 (-) 或转染带有 Myc-DDK 标签的人全长野生型 PGC-1α (+) 的表达载体的 293T 细胞的提取物进行蛋白质印迹分析。

PGC-1α, a critical booster of mitochondrial function, is an excellent candidate for preventing insulin resistance and metabolic syndromes secondary to mitochondrial dysfunction. PGC-1α has been shown to influence energy metabolism.

Here we identify inactivation of the transcriptional regulator PGC‐1α as a landmark for experimental nephrotoxic acute kidney injury (AKI) and describe the in vivo consequences of PGC‐1α deficiency over inflammation and cell death in kidney injury.

The transcriptional co-activator PGC-1 alpha (PGC-1α) was initially identified as a peroxisome proliferator-activated receptor-gamma ()-interacting protein from brown adipose tissue (BAT) that was involved in regulating the process of adaptive thermogenesis in

PGC-1α is a transcriptional coactivator that regulates the genes involved in energy metabolism. It is the master regulator of mitochondrial biogenesis. This protein interacts with the nuclear receptor PPAR-γ, which permits the interaction of this protein with multiple transcription factors

SR-18292 是一种 PPARγ 共激活因子-1α (PGC-1α) 抑制剂,可促进 PGC-1α 乙酰化,抑制糖异生基因的表达,并减少肝细胞中葡萄糖的产生。- 高纯度,全球文献引用。

Qian et al. demonstrated that KDM3A functions as an oxygen sensor and demethylates K224-monomethylated PGC-1α under normoxic conditions. Hypoxia inhibits KDM3A activity and increases PGC-1α K224 monomethylation, resulting in the inhibition of PGC-1α

1/12/2006 · The PGC-1α gene is located on chromosome 5 in mice (chromosome 4 in humans) and encodes a protein containing 797 (mouse) or 798 amino acids (human). PGC-1α has two putative nuclear localization signals and is located in the cell nucleus ().

Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of


PGC-1α repression causes RPE mitochondrial dysfunction and oxidative stress To investigate the role of PGC-1α in RPE metabolism, integrity, and function, we silenced PGC-1α in the human RPE cell line ARPE-19 by lentivirus-mediated delivery of shRNA.

Anti-PGC-1α Mouse mAb (4C1.3) 1 Product Result | Match Criteria: Product Name ST1202 This Anti-PGC-1α Mouse mAb (4C1.3) is validated for use in Immunoblotting, Immunocytochemistry, Immunoprecipitation, Paraffin Sections for the detection of PGC-1α

PGC-1α (H-300) has been discontinued and replaced by PGC-1α (D-5): sc-518025. This new monoclonal antibody is more specific, provides a stronger signal and eliminates lot to lot variation characteristic of most, if not all, polyclonal antibodies.


11/3/2019 · Endurance exercise training prevents atherosclerosis. Peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) increases myokine secretion from the skeletal muscle, and these myokines have been shown to affect the function of multiple organs. Since

Fourth, PGC-1α-siRNA-treated fibroblasts show reduced fibrotic marker production and a lower level of profibrotic expression compared with non-silenced renal fibroblasts. Fifth, PGC-1α regulates renal interstitial fibrosis through TGF-β1-activated TGFβ-RI, PI3K).

PGC-1α plays a critical role in mitochondrial biogenesis in muscle, and in influencing whether muscle contains slow-twitch fatigue-resistant oxidative fibers (type I and IIA fibers, rich in mitochondria, use oxidative phosphorylation to generate ATP) or fast-twitch.


18/5/2018 · Transcriptional coactivator PGC-1α and its splice variant NT-PGC-1α play crucial roles in regulating cold-induced thermogenesis in brown adipose tissue (BAT). PGC-1α and NT-PGC-1α are highly induced by cold in BAT and subsequently bind to and coactivate

PGC‐1α is decreased in various in vivo models of heart failure, including transverse aortic constriction (TAC) in mice (Arany et al., 2006; Huss et al., 2007) and congestive heart failure in rats (Garnier et al., 2003), suggesting that decreased PGC‐1α is a common

PGC-1α Antibody (D-5) is a mouse monoclonal IgG 2a (kappa light chain) provided at 200 µg/ml raised against amino acids 1-300 mapping near the N-terminus of PGC-1α of human origin PGC-1 alpha Antibody (D-5) is recommended for detection of PGC-1α of


This Anti-PGC-1α Mouse mAb (4C1.3) is validated for use in Immunoblotting, Immunocytochemistry, Immunoprecipitation, Paraffin Sections for the detection of PGC-1α. – Find MSDS or SDS, a COA, data sheets and more information.

16/6/2016 · PGC-1α controls thermogenesis in brown fat and white-to-brown adipocyte differentiation. 24,25 In skeletal muscle, PGC-1α increases insulin sensitivity and regulates fiber-type switching. 26,27 Increases in PGC-1α can also prevent muscle atrophy. 28 29 24 30

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PGC-1α (D-5) is a mouse monoclonal antibody raised against amino acids 1-300 mapping near the N-terminus of PGC-1α of human origin. PRODUCT Each vial contains 200 µg IgG 2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1%

PGC-1α also uses different non-LXXLL domains to interact with certain other transcription factors: a domain between amino acids 200 and 400 interacts with PPARγ and NRF-1 and a region between amino acids 400 to 500 that interacts with MEF2-C ().


1/12/2009 · Aging is a major risk factor for metabolic disease and loss of skeletal muscle mass and strength, a condition known as sarcopenia. Both conditions present a major health burden to the elderly population. Here, we analyzed the effect of mildly increased PGC-1α